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Metformin and metabolic diseases: a focus on hepatic aspects

Juan Zheng,Shih-Lung Woo,Xiang Hu,Rachel Botchlett,Lulu Chen,Yuqing Huo,Chaodong Wu

Frontiers of Medicine 2015, Volume 9, Issue 2,   Pages 173-186 doi: 10.1007/s11684-015-0384-0

Abstract: In addition, metformin is generally safe and may also benefit patients with other chronic liver diseases

Keywords： metformin     diabetes     hepatic steatosis     inflammatory response     insulin resistance    

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A Screening Model for Probiotics Against Specific Metabolic Diseases Based on Caco-2 Monolayer Membrane Article

Yang Liu, Jiang Peng, Shiya Zhu, Leilei Yu, Fengwei Tian, Jianxin Zhao, Hao Zhang, Wei Chen, Qixiao Zhai

Engineering 2023, Volume 25, Issue 6,   Pages 222-233 doi: 10.1016/j.eng.2022.02.014

Abstract:

Recent studies have revealed the potency of probiotics in alleviating metabolic diseases associatedHowever, an efficient model for screening probiotic strains against specific metabolic diseases has notcell monolayer membrane model for the efficient screening of potential probiotics against specific metabolicdiseases such as osteoporosis and chronic alcoholic liver disease.

Keywords： Lactobacillus     Intestinal barrier     Caco-2 cells     Screening model     Metabolic diseases    

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New insights into different surfactants’ impacts on sludge fermentation: Focusing on the particular metabolic

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 8, doi: 10.1007/s11783-022-1527-6

Abstract:

• The promoting effects for VFA generation follow the order of APG>SDBS>HTAB.

Keywords： Waste activated sludge (WAS)     Volatile fatty acids (VFA)     Surfactant types     Functional microorganisms     Metabolic    

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Metabolic hypertension: concept and practice

Zhiming Zhu, Peijian Wang, Shuangtao Ma

Frontiers of Medicine 2013, Volume 7, Issue 2,   Pages 201-206 doi: 10.1007/s11684-013-0264-4

Abstract: More than 60% of the risk factors for hypertension are associated with metabolic disturbances.Metabolic abnormalities increase the risk for hypertension and cause high blood pressure.Improving metabolic disturbances is beneficial for hypertension treatment.Due to the importance of metabolic abnormalities in the pathogenesis of hypertension, we propose a conceptof metabolic hypertension.

Keywords： hypertension     cardiometabolic risk factors     metabolic abnormalities    

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The Human Microbiota in Health and Disease

Baohong Wang, Mingfei Yao, Longxian Lv, Zongxin Ling, Lanjuan Li

Engineering 2017, Volume 3, Issue 1,   Pages 71-82 doi: 10.1016/J.ENG.2017.01.008

Abstract: microbial role in basic biological processes and in the development and progression of major human diseasessuch as infectious diseases, liver diseases, gastrointestinal cancers, metabolic diseases, respiratorydiseases, mental or psychological diseases, and autoimmune diseases.

Keywords： Microbiome     Health     Infectious disease     Liver diseases     Gastrointestinal malignancy     Metabolic disorder     Microbiota    

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Beneficial metabolic activities of inflammatory cytokine interleukin 15 in obesity and type 2 diabetes

Jianping Ye

Frontiers of Medicine 2015, Volume 9, Issue 2,   Pages 139-145 doi: 10.1007/s11684-015-0377-z

Abstract:

In obesity, chronic inflammation is believed to induce insulin resistance and impairs adipose tissue function. Although this view is supported by a large body of literature, it has been challenged by growing evidence that pro-inflammatory cytokines may favor insulin sensitivity through induction of energy expenditure. In this review article, interleukin 15 (IL-15) is used as a new example to explain the beneficial effects of the pro-inflammatory cytokines. IL-15 is secreted by multiple types of cells including macrophages, neutrophils and skeletal muscle cells. IL-15 expression is induced in immune cells by endotoxin and in muscle cells by physical exercise. Its transcription is induced by transcription factor NF-κB. IL-15 binds to its receptor that contains three different subunits (α, β and γ) to activate JAK/STAT, PI3K/Akt, IKK/NF-κB and JNK/AP1 pathways in cells. In the regulation of metabolism, IL-15 reduces weight gain without inhibiting food intake in rodents. IL-15 suppresses lipogenesis, stimulates brown fat function, improves insulin sensitivity through weight loss and energy expenditure. In human, circulating IL-15 is negatively associated with body weight. In the immune system, IL-15 stimulates proliferation and differentiation of T cells, NK cells, monocytes and neutrophils. In the anti-obesity effects of IL-15, T cells and NK cells are not required, but leptin receptor is required. In summary, evidence from human and rodents supports that the pro-inflammatory cytokine IL-15 may enhance energy expenditure to protect the body from obesity and type 2 diabetes. The mechanism of IL-15 action remains to be fully uncovered in the regulation of energy expenditure.

Keywords： inflammation     obesity     cytokine     energy expenditure     insulin resistance    

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electron transfer and its application in dictating routes of biochemical processes associated with metabolic

Frontiers of Medicine 2021, Volume 15, Issue 5,   Pages 679-692 doi: 10.1007/s11684-021-0866-1

Abstract: Metabolic reprogramming, such as abnormal utilization of glucose, addiction to glutamine, and increasedelectron transfer (PET), which is used to characterize the degree of electron redistribution coupled with metabolicEnabling electron transfer could drive metabolic reprogramming in cancer metabolism.

Keywords： metabolic reprogramming     potential of electron transfer     cell proliferation     aerobic glycolysis     cancer    

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Fibroblast growth factor 21: a novel metabolic regulator from pharmacology to physiology

Huating Li, Jing Zhang, Weiping Jia

Frontiers of Medicine 2013, Volume 7, Issue 1,   Pages 25-30 doi: 10.1007/s11684-013-0244-8

Abstract: relevance of FGF21 in humans is still unclear, and the basis and consequences of increased FGF21 in metabolicpharmacological actions and physiological roles make FGF21 attractive drug candidates for treating metabolic

Keywords： FGF21     metabolism     pharmacology     physiology     clinical relevance    

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Laparoscopic treatment of liver diseases in children

Jia Wei, Jiexiong Feng

Frontiers of Medicine 2011, Volume 5, Issue 4,   Pages 388-394 doi: 10.1007/s11684-011-0165-3

Abstract: Laparoscopic liver surgery has been increasingly used for the treatment of pediatric liver diseases overapplication of various laparoscopic instruments and the methods used for the laparoscopic treatment of liver diseases

Keywords： laparoscopic surgery     liver mass     pediatric    

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denitrification system with short-term pyridine exposure: Process capability, inhibition kinetics and metabolic

Frontiers of Environmental Science & Engineering 2021, Volume 15, Issue 6, doi: 10.1007/s11783-021-1433-3

Abstract:

• Short-term effect of the pyridine exposure on the SAD process was investigated.

Keywords： Anammox     Inhibition     Metabolic pathway     Microbial community     Pyridine     SAD    

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Prevalence of cardiovascular diseases in China

Jun-Jie XIAO MD, Yi-Han CHEN MD, PhD,

Frontiers of Medicine 2010, Volume 4, Issue 1,   Pages 16-20 doi: 10.1007/s11684-010-0007-8

Abstract: Cardiovascular diseases (CVD) cause one third of all deaths in China, and the number is anticipated to

Keywords： cardiovascular diseases     prevalence     China     risk factors     prevention    

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Water-dispersible nano-pollutions reshape microbial metabolism in type-specific manners: A metabolic

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 9, doi: 10.1007/s11783-022-1548-1

Abstract:

• Water-dispersible nano-pollutions exhibit type-specific toxic effects on E. coli.

Keywords： Nano-toxicity     Nano-plastics     Quantum dots     Microbial metabolite     Metabolic dysregulation    

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The FGF metabolic axis

Xiaokun Li

Frontiers of Medicine 2019, Volume 13, Issue 5,   Pages 511-530 doi: 10.1007/s11684-019-0711-y

Abstract: Members of the fibroblast growth factor (FGF) family play pleiotropic roles in cellular and metabolicFGF19 metabolic axis from the ileum to liver negatively controls diurnal bile acid biosynthesis.FGF21 metabolic axes play multifaceted roles in controlling the homeostasis of lipid, glucose, and energyFGF23 axes from the bone to kidney and parathyroid regulate metabolic homeostasis of phosphate, calciumThus, the term “FGF Metabolic Axis,” which distinguishes the unique pathways and functions of endocrine

Keywords： FGF19     FGF21     FGF23     FGFR     metabolism     endocrine     Klotho    

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Cultural differences define diagnosis and genomic medicine practice: implications for undiagnosed diseases

Xiaohong Duan, Thomas Markello, David Adams, Camilo Toro, Cynthia Tifft, William A. Gahl, Cornelius F. Boerkoel

Frontiers of Medicine 2013, Volume 7, Issue 3,   Pages 389-394 doi: 10.1007/s11684-013-0281-3

Abstract: Specifically, we suggest that an undiagnosed diseases program in China will differ from the recentlyestablished Undiagnosed Diseases Program at the United States National Institutes of Health; a culturally

Keywords： genetics     cultural differences     undiagnosed diseases program    

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Diagnosis and therapy of lacrimal system diseases by micro lacrimal endoscope

Nan XIANG, Weikun HU, Jing YUAN, Guigang LI, Haixia LIU

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 113-117 doi: 10.1007/s11684-009-0001-1

Abstract: membranes, the characteristics of pathological changes and the predilection sites of lacrimal system diseasesThe lacrimal endoscope is a new method in the diagnosis of lacrimal system diseases.therapy under orthophoria, it will bring a great change to the diagnosis and therapy of lacrimal system diseases

Keywords： lacrimal apparatus diseases     endoscopes    

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Title Author Date Type Operation

Metformin and metabolic diseases: a focus on hepatic aspects

Juan Zheng,Shih-Lung Woo,Xiang Hu,Rachel Botchlett,Lulu Chen,Yuqing Huo,Chaodong Wu

Journal Article

A Screening Model for Probiotics Against Specific Metabolic Diseases Based on Caco-2 Monolayer Membrane

Yang Liu, Jiang Peng, Shiya Zhu, Leilei Yu, Fengwei Tian, Jianxin Zhao, Hao Zhang, Wei Chen, Qixiao Zhai

Journal Article

New insights into different surfactants’ impacts on sludge fermentation: Focusing on the particular metabolic

Journal Article

Metabolic hypertension: concept and practice

Zhiming Zhu, Peijian Wang, Shuangtao Ma

Journal Article

The Human Microbiota in Health and Disease

Baohong Wang, Mingfei Yao, Longxian Lv, Zongxin Ling, Lanjuan Li

Journal Article

Beneficial metabolic activities of inflammatory cytokine interleukin 15 in obesity and type 2 diabetes

Jianping Ye

Journal Article

electron transfer and its application in dictating routes of biochemical processes associated with metabolic

Journal Article

Fibroblast growth factor 21: a novel metabolic regulator from pharmacology to physiology

Huating Li, Jing Zhang, Weiping Jia

Journal Article

Laparoscopic treatment of liver diseases in children

Jia Wei, Jiexiong Feng

Journal Article

denitrification system with short-term pyridine exposure: Process capability, inhibition kinetics and metabolic

Journal Article

Prevalence of cardiovascular diseases in China

Jun-Jie XIAO MD, Yi-Han CHEN MD, PhD,

Journal Article

Water-dispersible nano-pollutions reshape microbial metabolism in type-specific manners: A metabolic

Journal Article

The FGF metabolic axis

Xiaokun Li

Journal Article

Cultural differences define diagnosis and genomic medicine practice: implications for undiagnosed diseases

Xiaohong Duan, Thomas Markello, David Adams, Camilo Toro, Cynthia Tifft, William A. Gahl, Cornelius F. Boerkoel

Journal Article

Diagnosis and therapy of lacrimal system diseases by micro lacrimal endoscope

Nan XIANG, Weikun HU, Jing YUAN, Guigang LI, Haixia LIU

Journal Article